Antitussive Activity of Narcotine Derivatives
نویسندگان
چکیده
منابع مشابه
The use of noscapine (narcotine) as an antitussive agent.
cal formula is C2H2307N. Actually Noscapine bears little resemblance to the narcotic alkaloids, either chemically or pharmacologically. The structure of morphine, codeine, and similar compounds is based on a phenanthrene nucleus, whereas Noscapine is an isoquinoline derivative (related to papaverine). It is readily absorbed after oral or parenteral administration, disappears rapidly from the bl...
متن کاملThe antitussive effect of dextromethorphan in relation to CYP2D6 activity.
AIMS To test the hypothesis that inhibition of cytochrome P450 2D6 (CYP2D6) by quinidine increases the antitussive effect of dextromethorphan (DEX) in an induced cough model. METHODS Twenty-two healthy extensive metaboliser phenotypes for CYP2D6 were studied according to a double-blind, randomised cross-over design after administration of: (1) Placebo antitussive preceded at 1 h by placebo in...
متن کاملAntitussive activity of iodo-resiniferatoxin in guinea pigs.
BACKGROUND Iodo-resiniferatoxin (I-RTX) has recently been described as an ultra potent antagonist of the transient receptor potential vanilloid-1 (TRPV1). METHODS The ability of I-RTX to inhibit cough induced by inhalation of two putative TRPV1 stimulants (capsaicin and citric acid) was tested in non-anaesthetised guinea pigs. RESULTS Pretreatment with I-RTX either intraperitoneally (0.03-0...
متن کاملSynthesis and Insecticide Activity of Octahydroquinazolinone derivatives
A simple method for the synthesis of octahydroquinazolinone derivatives in the presence of BF3.SiO2 and Insecticide activity of these compounds against spodoptera litura was investigated to be comparable to commercial pyrethroid insecticides, Cypermethrin and Cyhalothrin. The structure of the isolated compounds was characterized by 1HNMR and FT-IR spectroscopy.The proposed method had some ad...
متن کاملcomparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1964
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.12.569